KEGG   Homo sapiens (human): 249
Entry
249               CDS       T01001                                 
Symbol
ALPL, AP-TNAP, APTNAP, HOPS, HPPA, HPPC, HPPI, HPPO, TNALP, TNAP, TNS-ALP, TNSALP
Name
(RefSeq) alkaline phosphatase, biomineralization associated
  KO
K01077  alkaline phosphatase [EC:3.1.3.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00730  Thiamine metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Disease
H00213  Hypophosphatasia
Drug target
Asfotase alfa: D10595<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    249 (ALPL)
   00790 Folate biosynthesis
    249 (ALPL)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    249 (ALPL)
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    249 (ALPL)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.1  alkaline phosphatase
     249 (ALPL)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   249 (ALPL)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Enzymes
  249 (ALPL)
SSDB
Motif
Pfam: Alk_phosphatase Metalloenzyme
Other DBs
NCBI-GeneID: 249
NCBI-ProteinID: NP_000469
OMIM: 171760
HGNC: 438
Ensembl: ENSG00000162551
UniProt: P05186
Structure
Position
1:21508984..21578410
AA seq 524 aa
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
NT seq 1575 nt   +upstreamnt  +downstreamnt
atgatttcaccattcttagtactggccattggcacctgccttactaactccttagtgcca
gagaaagagaaagaccccaagtactggcgagaccaagcgcaagagacactgaaatatgcc
ctggagcttcagaagctcaacaccaacgtggctaagaatgtcatcatgttcctgggagat
gggatgggtgtctccacagtgacggctgcccgcatcctcaagggtcagctccaccacaac
cctggggaggagaccaggctggagatggacaagttccccttcgtggccctctccaagacg
tacaacaccaatgcccaggtccctgacagtgccggcaccgccaccgcctacctgtgtggg
gtgaaggccaatgagggcaccgtgggggtaagcgcagccactgagcgttcccggtgcaac
accacccaggggaacgaggtcacctccatcctgcgctgggccaaggacgctgggaaatct
gtgggcattgtgaccaccacgagagtgaaccatgccacccccagcgccgcctacgcccac
tcggctgaccgggactggtactcagacaacgagatgccccctgaggccttgagccagggc
tgtaaggacatcgcctaccagctcatgcataacatcagggacattgacgtgatcatgggg
ggtggccggaaatacatgtaccccaagaataaaactgatgtggagtatgagagtgacgag
aaagccaggggcacgaggctggacggcctggacctcgttgacacctggaagagcttcaaa
ccgagatacaagcactcccacttcatctggaaccgcacggaactcctgacccttgacccc
cacaatgtggactacctattgggtctcttcgagccaggggacatgcagtacgagctgaac
aggaacaacgtgacggacccgtcactctccgagatggtggtggtggccatccagatcctg
cggaagaaccccaaaggcttcttcttgctggtggaaggaggcagaattgaccacgggcac
catgaaggaaaagccaagcaggccctgcatgaggcggtggagatggaccgggccatcggg
caggcaggcagcttgacctcctcggaagacactctgaccgtggtcactgcggaccattcc
cacgtcttcacatttggtggatacaccccccgtggcaactctatctttggtctggccccc
atgctgagtgacacagacaagaagcccttcactgccatcctgtatggcaatgggcctggc
tacaaggtggtgggcggtgaacgagagaatgtctccatggtggactatgctcacaacaac
taccaggcgcagtctgctgtgcccctgcgccacgagacccacggcggggaggacgtggcc
gtcttctccaagggccccatggcgcacctgctgcacggcgtccacgagcagaactacgtc
ccccacgtgatggcgtatgcagcctgcatcggggccaacctcggccactgtgctcctgcc
agctcggcaggcagccttgctgcaggccccctgctgctcgcgctggccctctaccccctg
agcgtcctgttctga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (5)   
   KEGG DISEASE (1)   
   OMIM (4)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (50)   
   RefSeq(nuc) (8)   
   GenBank (21)   
   EMBL (21)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (103)   

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